DATABASES
- SYNTHETIC TECHNIQUES / NATURAL PRODUCTS
... lists over 32K natural products with a heterocyclic ring system whose structure has been determined since 1975. Data from 36 international journals.
Searchable by Name (as used in the literature), MF, MW, Natural Source, Author, Journal Name.
Heterocycles (Synthesis Menu)
Searchable by Name (as used in the literature), MF, MW, Author, Journal Name.
Heterocycles Web Edition - Most recent 20 articles - free PDF
Heterocycles Web Edition - Abstracts/figures/tables/references (v.52, 2000+) [click Library]
http://www.heterocycles.jp/index.php
Organic
Syntheses (ONLINE)
Organic Syntheses are detailed experimental methods for the synthesis of organic compounds. In some 77 annual volumes and 9 collective volumes published by John Wiley & Sons, Inc. OS joins the digital era by providing a collective version of Organic Syntheses in a fully searchable electronic format, on the Web.
Search categories (e.g. exact and substructure searches, chemical name, formula, OS reference, keywords) are listed on the search page found after the Hazard Warning. Clicking on the preparation titles which appear as initial “hits” following a “new search”, the individual OS preparations are displayed, including the full text, structures, and illustrations. Highlighted compounds are linked to their Chemical Abstracts registry numbers and to other pages in the database where they also appear.
IMPORTANT: Before using this website, please check the System Requirements and Plugin
Downloads page and make sure that you are using a supported browser, and have downloaded and
installed the latest ChemDraw Plugin.
Quick Guide to ChemDraw: http://www.shef.ac.uk/misc/personal/ch1mjm/teaching/Chem.htm
Methods in Organic Synthesis
http://www.rsc.org/Publishing/CurrentAwareness/index.asp
Methods in Organic Synthesis (MOS) is a monthly web alerting service, containing over 200 new graphical reaction schemes, representing the most important current developments in organic synthesis, including such topics as functional group changes, introduction of chiral centers, and enzyme/biological transformations.
MOS Database is a text searchable database that is a cumulation of the monthly issues since January 2000+.
MOS Database allows searching by: Reagent, Reaction, Reactant, Product (added index terms that are not displayed) — and bibliographic data (e.g. author, title words, etc).
The ‘help’ link on the MOS Online Search Page gives details:
http://www.rsc.org/Publishing/CurrentAwareness/MOS/MOSOnlineHelp.asp
A Source List of the key journals monitored (with abbreviations for searching) is available at:
http://www.rsc.org/Publishing/CurrentAwareness/MOS/SourceList.asp
Natural
Product Updates
http://www.rsc.org/is/database/npuhome.htm
Natural Product Updates (NPU) is a monthly web alerting service, containing over 200 new graphical reaction schemes, representing the most important developments in Natural Product Chemistry. It describes new natural products, known compounds from new sources, isolation studies, structural determinations, new properties and activities, biosynthesis and biological activities.
NPU is also a text searchable database that is a cumulation of the monthly issues since January 2000+.
NPU allows searching by: Non-plant sources,Taxonomic names, Biological activity, Compound Class and Trivial names (added index terms that
are not displayed) —and bibliographic data (e.g. author, title words, etc).
The ‘help’ link on the NPU Search Page gives details < http://www.rsc.org/CFNPU/NPUSearchPage.cfm >
A Source List of the key journals monitored (with abbreviations for searching) is available at:
http://www.rsc.org/CFNPU/helpnpujlist.cfm?#PassParameters
Novel Antibiotics Database
http://www.antibiotics.or.jp/journal/database/database-top.htm
...includes 5,430 novel substances published in the Journal of Antibiotics Vol. 1-56, in 1947-2003
SciFinder
Scholar - Registry File
http://library.caltech.edu/publications/scifinder/
SciFinder Scholar provides access to journal articles and patents in CAplus that describe synthetic preparations and information on natural products. After searching for a compound by Structure, Name, CAS Registry Number, or Molecular Formula, Click on 'Get References'. This will display a dialog box where the references can be limited to preparations (which includes both preparative reactions and extraction techniques from natural materials).
A search on Taxol, for example, retrieves over 1500 articles & patents that describe its synthesis or isolation.
SciFinder
Scholar - CAS React
http://library.caltech.edu/publications/scifinder/
Another approach is to search CAS React, which is a structure-based file of organic/organometallic synthetic reactions (1840+). Preparative reactions for specific reactants and products, either drawn or imported via CAS Registry Numbers (using paste under the edit menu), are searched by 1) clicking 'Lock All Positions' (under the Tools menu), 2) highlighting the compound with the A à B tool, 3) clicking both the 'product' radio button and OK, and 4) clicking 'Get Reactions'. Alternatively you can draw or import a single structure, designate 'product' and click 'Get Reactions'., this obviously does not put any limits on reactants.
Searching for 4-halophenol as a reactant and 4-hydroxy-6-halocoumarin as a product
currently retrieves 4 (graphical) synthetic reactions, each with a journal reference.
SyntheticPages
ORGANIC
REACTIONS AND SYNTHESIS: Bibliography
Texts
and Monographs (see CLAS for call numbers & locations)
Comprehensive Organic Transformations. R. Larock, VCH, (2nd.ed.1999)
Best Synthetic Methods (currently 24 volumes)
Some Modern Methods of Organic Synthesis, 4th ed, W. Carruthers, CUP (2004)
Name reactions : a collection of detailed reaction mechanisms. Jie Jack Li, Springer (2003)
Organic Synthesis, Michael B. Smith, McGraw Hill (2nd ed. 2002)
Search CLAS … Course Reserves … Ch242 for additional books
Series
and Compendia (see CLAS for call numbers & locations)
Chemistry of Functional Groups
Compendium of Organic Synthetic Methods, 1971+
Comprehensive Organic Functional Group Transformations. I(1995) & II(2005) -- Searchable thru
DiscoveryGate
Comprehensive Organic Synthesis, 1991
Encyclopedia of Reagents for Organic Synthesis
Searchable online as EROS 1995+
Fieser and Fieser's Reagents for Organic Chemistry, 1967+
Methoden der Organischen Chemie, Houben-Weyl, 1952-2002
Encyclopedia of Reagents for Organic Synthesis -- Searchable online as EROS 1995+
Organic Syntheses, 1921+
Searchable thru DiscoveryGate